Peptides: The Longevity Tool Your Doctor Has Never Mentioned ft. Dr. Mary Pines

Peptides, Perimenopause & the Wellness Tool Nobody Is Talking About ft. Dr. Mary Pines
Listener Gina had a question: what's the deal with peptides — the ones that aren't GLP-1s, the ones all over social media? Are they legit or total BS? Danna immediately said: Mary. Dr. Mary Pines is back on SFH for the first time in three years, neck-deep in the peptide scene and ready to spill everything.
About Dr. Mary Pines: PhD-level functional medicine practitioner specializing in hormonal and metabolic health for midlife women. She's been working with peptides for nearly a decade and recently folded peptide therapy into her 12-week program Better Beyond 40. She also hosts The Better Beyond Podcast — and yes, Danna was a guest on it. Check out that episode.
What You'll Learn:
- What peptides actually are and how they differ from hormones
- The Cold War origin story of BPC-157 (Soviet super soldiers, no joke)
- The autoimmune and allergy connection — and the peptide that can calm a haywire immune system
- Whether lifestyle alone can boost peptide production naturally
- Why sourcing is the single biggest issue — and what to watch out for
- The four peptides worth knowing about as starting points
- Why peptides are never step one, and what needs to come first
Real Talk Moments: Danna asks if there's a peptide that can kill cortisol. The answer is a compassionate "no — but also maybe." She also opens up about doing everything right and still waking at 4:30am wired and suffering. Turns out Dr. Mary's functional medicine doctor has the same problem. The solidarity was real. Megan, meanwhile, catches Dr. Mary appearing on another podcast and declares full mock-betrayal: "Cheating on me with another podcast."
Dr. Mary's Parting Wisdom: "Your body knows what to do with these things. We're really just replacing something that was lost."
Connect with Dr. Mary Pines: Everything you need to know about Mary can be found on her website: https://bit.ly/4uH6yWE
Get in touch!
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Chapters:
00:00 Peptides Who They’re For
04:00 What Peptides Are and Why They Work
11:56 Immune Balance GLP-1 and Lifestyle Boosts
19:43 Symptoms Labs First
22:08 Peptide Sourcing Reality
26:02 Top Peptides and Wrap
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00:00 - Untitled
00:16 - Introduction
04:16 - What Peptides Are and Why They Work
12:40 - Immune Balance GLP-1 and Lifestyle Boosts
20:27 - Symptoms Labs First
22:53 - Peptide Sourcing Reality
27:08 - Top Peptides and Wrap
They're a mainstay in functional medicine in both Europe and North America.
Speaker AAnd who should and shouldn't use peptides?
Speaker AIt's a tricky question because in my view, I think the peptides are rising here quickly and I think these things would be everywhere and I think that a lot of people would be using them and I would think that would be actually really good.
Speaker AThe problem is sourcing, which we'll get to.
Speaker ABut as to who can benefit, honestly, I think everybody.
Speaker AThere are certain ones that everybody can benefit from.
Speaker AIn studies, they show a person can take a thousand times the dose and be totally fine.
Speaker AYour body knows what to do with these things.
Speaker ASo we're really like hormone replacement, replacing something that was lost.
Speaker AAnd we can feel into which peptides are appropriate for us or not in the moment.
Speaker AHi, I'm Dr. Mary Pines and I'm today's guest on the so frickin Healthy podcast.
Speaker AI am passionate about transforming the health and lives of midlife women struggling with perimenopause and menopause hormone and metabolic issues through personalized science backed methods that include peptides.
Speaker AAnd on today's episode, we talk all about peptides.
Speaker BHey, Donna, how you doing today?
Speaker COkay, how are you doing today, Megan?
Speaker BCould you do it again?
Speaker BBecause you sounded not okay.
Speaker AReady?
Speaker BDonna, how you doing today?
Speaker BI'm all right.
Speaker CHow are you doing today, Megan?
Speaker ANot any better, but we'll stick with it.
Speaker AI'm okay.
Speaker AI'm also a little, I feel a.
Speaker BLittle low energy today.
Speaker BI'm going to blame it on the allergies.
Speaker BMy body's still struggling a little bit with the allergies.
Speaker BUm, but I want to keep our intro short this time because we have.
Speaker ASo much to talk about.
Speaker CWe have a lot to talk about.
Speaker BAnd we have one of our favorite guests back, back with us today, Dr. Mary Pines.
Speaker BHello, Dr. Mary Pines.
Speaker BHow are you today?
Speaker AOh, hello.
Speaker AOh, you're good.
Speaker BMy favorite too.
Speaker AThis is exciting.
Speaker AI woke up giddy this morning.
Speaker AI'm over here on the west coast of Canada, so it's morning for me and I'm bright eyed, bushy tailed and excited to chat with you today.
Speaker AAnd I have something for allergy, by the way, which is related to our topic, so.
Speaker CLook at her.
Speaker AOkay, baby, gonna be fun.
Speaker BSo we knew we wanted to have you back on just because we love talking to you.
Speaker CBut it's been a, it's been a.
Speaker BHot minute since we had you on the podcast probably more than three years ago.
Speaker BAnd we were just like, what do we want to talk To Mary about.
Speaker BAnd then one of our all time favorite listeners, Gina, she sent us a voicemail.
Speaker ANow that I have your phone number, I don't just have to send my commands to Donna, I can also send them to you.
Speaker ACan we please have a guest on.
Speaker BThat talks about peptides.
Speaker BPeptides other than the GLP1s, which I.
Speaker AThink everyone a little bit saturated on those and you know, act limited.
Speaker ABut these other peptides we're hearing about on social media, are they all bogus?
Speaker AAre they something that actually we could.
Speaker BUse as a lever?
Speaker AOr are we going to be taking things that are actually bad for our health?
Speaker BAnd the unregulated would love to know.
Speaker AThanks, Gina.
Speaker AI love that as soon as she.
Speaker BMentioned this, Donna's like, Mary.
Speaker BThat's what we need to talk to Mary about.
Speaker BSo, Mary, I feel like you are in on the peptide scene.
Speaker CSo where would you like to start?
Speaker AOh, I am neck deep in the peptide scene.
Speaker AIt is the best.
Speaker AAnd I will say that I've been in it for a lot longer than GLP ones have been popular on the scene.
Speaker AIt's probably been 10 years now.
Speaker AAnd I have definitely used them for my own benefit greatly.
Speaker AThey have changed my life.
Speaker ASo I'm super glad you reached out and thank you, Gina, for that question.
Speaker AIt's a great one because, oh my God, the amount of brewha on the Internet, as per usual, what we would expect when anything new, quote unquote comes up.
Speaker AAnd I would say actually to that point, peptides aren't really that new.
Speaker AThey've been around a long time and we'll get to that in a sec.
Speaker ABut like high level, what the heck is a peptide?
Speaker AA peptide is just a fancy word for a little tiny baby protein.
Speaker AAnd a protein, if you remember from science, is just a bunch of amino acids strung together in a row.
Speaker ASo when you eat your protein, your meat, you take your collagen in your coffee, your body takes those things and breaks them down and then puts them back into these little string of proteins or little baby proteins called peptide.
Speaker AAnd in the case of peptides, they are like master signaling molecules in the body.
Speaker AThey're wide reaching, they're a little bit like hormones, but you can think of them as more specific, which is very cool.
Speaker AHormones are awesome.
Speaker AYou have to be careful with them because they have what's called pleiotropic effects, effects across the entire body.
Speaker AHowever, when it comes to peptide, they would actually consider to be safer because they're like little kind of molecular scissors, little molecular toolkit.
Speaker AWe can target very specific things with.
Speaker AAnd that's really cool.
Speaker AThere's ones for immune health.
Speaker AWe touched on allergies a second ago.
Speaker AWe obviously know about the GLP ones very wide reaching benefits.
Speaker AThere's ones for tissue remodeling and healing post surgery or if you have old scar tissue.
Speaker AThere's a million different things we can do with them.
Speaker AIt's very cool.
Speaker AThere's a lot of them.
Speaker AAnd actually in Europe and Russia is where they were pioneered.
Speaker AAnd they were pioneered in the Cold War by a brilliant scientist who was trying to make so called super soldiers that healed really quickly and he actually was pretty successful.
Speaker AAnd the peptide he I would say discovered from human gastric juice that stomach juice has the capacity.
Speaker AYeah, I know, farming, right.
Speaker AHe was just trying all these different things and noticed that there was something in the extract of this stuff which we all produced which could make the soldiers heal almost twice as fast.
Speaker AAnd this is a peptide called BPC157.
Speaker AIt's one of the most popular ones you'll hear about.
Speaker AProbably G90 are thinking about that one.
Speaker AThat one so good, so safe, can really help to heal the body quickly.
Speaker AAnd there's lots of other different ones.
Speaker ABut basically our bodies produce lots of them when we're young, when we're fit and healthy.
Speaker AAnd then like hormones, unfortunately they decline over time.
Speaker ABut we can add them back and the body knows what to do with them.
Speaker AAnd they're really for the most part pretty safe.
Speaker AYou just really need to, you need to be aware of a few things if you're using them and do them under the guidance of a care provider.
Speaker ASo I'll leave it at that.
Speaker ADid I cover?
Speaker BYeah, no, that's fine.
Speaker AOkay.
Speaker ARight.
Speaker BUm, how do we, how does one know if they should be taking peptides?
Speaker BI feel like everyone is saying now almost everybody can benefit from collagen.
Speaker BAnd I know we're not going to harp on GLP1s but there has been now additional information coming out besides the weight loss effect, but other things that are beneficial from even GLP1s but in general, like I was telling Donna right before we hit record, these were not on my radar at all in terms of as a longevity tool.
Speaker BSo how do we, how does one know if they should even ask?
Speaker BWhat do you.
Speaker AThat's a great question.
Speaker AI will say they're a mainstay in functional medicine in both Europe and North America.
Speaker AAnd who should and shouldn't use peptides.
Speaker AIt's a tricky question because in my view I think the Peptides are rising here quickly.
Speaker AAnd if it weren't for the influence of big pharma, who doesn't like peptides unless they can patent them because they're natural.
Speaker ARight.
Speaker AYou can't patent and make money off a natural molecule.
Speaker AI think these things would be everywhere, and I think that a lot of people would be using them, and I would think that would be actually really good.
Speaker AThe problem.
Speaker AThe problem is sourcing, which we'll get to.
Speaker ABut as to who can benefit, honestly, I think everybody.
Speaker AThere are certain ones that everybody can benefit from.
Speaker ABPC157, I believe, is one of those.
Speaker AAnd the research shows that it and a few others are, like, so safe.
Speaker AIn studies, they show, like, a person can take a thousand times the dose and be totally fine.
Speaker AIt's really interesting.
Speaker AYour body knows what to do with these things.
Speaker AAnd I think there's many that everybody can benefit from.
Speaker AAnd in the longevity space, people like myself are taking a nice little suite of these things cyclically.
Speaker AOnce, twice, three, four times a year.
Speaker ASome of my favorite longevity experts do.
Speaker AEvery couple of months, they'll cycle in a new peptide or 2 or 3.
Speaker AAnd that's my approach as well.
Speaker ASo we're really like hormone replacement, replacing something that was lost.
Speaker AAnd we can feel into which peptides are appropriate for us or not in the moment.
Speaker AYou mentioned the DLP ones, I.
Speaker AAnd all of the new data that has come out, like, everybody knows that these things were terribly vilified wrongly by the media initially.
Speaker AAnd this has to do with errors and dosing causing lots of bad side effects.
Speaker AAnd like, studies and Brad showing cancers that really don't have anything to do with the human body and how it works.
Speaker AAnd that stuff hasn't really panned out at all.
Speaker AAnd now we know, like, in North America, those GLP1s are indicated for cardiovascular disease, disease, for autoimmune disease are coming out, like, for all sorts of things.
Speaker AAnd as a longevity tool at a low level, at a microdose level, they're profound.
Speaker ATools like blood work will look night and day with microdosing of GLP1, and you'll probably feel a lot better too, which is super interesting asides.
Speaker AAnything to do with weight loss.
Speaker COkay, that's amazing.
Speaker CI had a couple of questions.
Speaker CI had a couple of questions.
Speaker CNow I'm like, I'm overflowing with beautiful information.
Speaker COne thing that you said which made me curious is you said that the studies show that a person can take up to a thousand times more, still be okay.
Speaker CSo I'm Curious what the body actually does with that influx of peptides, because do they go to waste?
Speaker CDo they go into a secret little camel storage?
Speaker CLike, how is that done?
Speaker CAnd then you also mentioned autoimmune, so I want you to answer that one, and then we'll talk about the autoimmune, because that's super exciting.
Speaker AOh, it is super exciting.
Speaker ASo there is no sort of, like, camel back or these peptides?
Speaker ANo, your body just turns them over.
Speaker AIt just.
Speaker APeptides tend to act at the surfaces of cells and float around in the bloodstream.
Speaker AAnd they're so small that they circulate to all of the tissues of the body, many of them.
Speaker ASo they come.
Speaker AThey range in, like, from two amino acids or three in length up to 49.
Speaker AThat's a range for peptides.
Speaker AMost of the therapeutic ones are in the lower end of that range.
Speaker AAnd so they're really tiny, and they can go everywhere to resolve issues.
Speaker ALike, you might not even be aware of that BPC 157, that you take it for knee pain or you have a shoulder surgery or something like this.
Speaker AThen you notice, ooh, my neck feels better, Ankle feels better.
Speaker ABut you won't be able to store that peptide in your body for later use.
Speaker ALike, you would take it daily, and then it would be gone.
Speaker ASo you take a thousand times too much, you saturate the kind of receptor for it or its docking site, and your body turns it over and gets rid of it.
Speaker AIt just chews it up and spits it out.
Speaker BGood.
Speaker CSo we know that we don't want to waste our time and money and effort and take extra, because that's not going to.
Speaker CIt doesn't do any damage, but it doesn't necessarily help in any other way, except for peeing it back out.
Speaker CAnd then you're literally flushing your money down the toilet.
Speaker AYeah.
Speaker CAnd peptides, I don't know.
Speaker CThe last time I took them was a few years ago, and they were stupidly expensive.
Speaker AI'm hoping the prices adjusted a little bit.
Speaker CBut with.
Speaker CI don't know.
Speaker CI'm sure Trump made sure that's not the case.
Speaker CYou said autoimmune.
Speaker CThat's insane.
Speaker CAs soon as you said that it could help autoimmune disease, I assume is what you meant.
Speaker AReverse.
Speaker CMy brain went to, of course.
Speaker CBecause it heals the leaky gut.
Speaker CAm I in the right direction or.
Speaker CIt's just.
Speaker CIt's doing a lot more magic than I even understand in terms of autoimmune.
Speaker AYeah, there.
Speaker AThere is definitely more magic.
Speaker AThere so there's one that I believe I remember you, you were taking, that does help to heal the gut.
Speaker AThere's a coup of those, and that's a piece of it.
Speaker ABut there's another one, thymus and alpha one, which is like the poster child for immune rebalancing.
Speaker ABecause what happens over time with age as a natural process of aging, or oftentimes with immune or allergies, to Megan's point, anytime that the immune system suddenly becomes reactive or maybe slowly becomes reactive over time with age, that could be a trauma, that could be overexposure to some allergen or toxin, that could be just development of autoimmune.
Speaker AThe immune system gets out of whack.
Speaker ASo there's this th1, th2 balance.
Speaker AAnd I doesn't matter what that means right now, but we basically veer towards an imbalance in those over time or with autoimmune or with a system that is highly reactive, say, with allergies.
Speaker AAnd so thymosin alpha 1 is thymic peptide produced by the thymus gland over time, with age, the thymus gland does this thing called involution.
Speaker AIt shrinks, basically.
Speaker AAnd this is part of the reason that we become less vital, we're less able to fight diseases of aging, that kind of stuff.
Speaker ASo we can add back in these thymic peptides.
Speaker AThere's a bunch of them, but Thymus, nalph1 is the leader in this rebalancing of the immune system to make it less reactive.
Speaker AAnd the cool thing about that is it really the dosing and the protocol.
Speaker ADana, to your question about autoimmune versus Megan's question about allergies.
Speaker AThe protocol and dosing would be different.
Speaker ADifferent timescale, different dosing, but same peptide to achieve those two ends.
Speaker AAnd, yeah, it's pretty cool.
Speaker AI have people, clients, friends, who I've supported with Imacin Alpha 1 who have had horrendous, like, seasonal allergies, and now they're like, oh, my God, this is a miracle.
Speaker AI have no more allergies.
Speaker AOr, like, with autoimmune, we can convince the immune system to, like, calm top, stop freaking out, go back into balance.
Speaker AThat's so cool.
Speaker BSo you mentioned that our body slowly stops producing quite as much of this.
Speaker BAnd I know when GLP1s hit the scene, there was a lot of people on social media that were saying, this is how you can boost GLP1 naturally.
Speaker BLike foods or exercise, whatever.
Speaker BSome kind of.
Speaker BYou don't have to inject it.
Speaker BSo are there peptides that we could, with lifestyle changes, whether that's sleep, nutrition, movement, stimulate them to create more peptides.
Speaker BAgain, can that work for people who are just like, I really don't want to have to take something forever or I don't have money to pay for it?
Speaker AIs that possible?
Speaker AGood question.
Speaker ATo a degree, sometimes, which you want me to answer.
Speaker ABecause just like hormones in your body, just like anything that your body wants to produce when it's at peak capacity, any insult to the body depletes our ability to make that thing, Whether it's a peptide or a hormone or a scaffolding protein or what have you.
Speaker AI would say if you want to boost how your body functions, how much of any given peptide you can produce, you want to be targeting inflammation, cellular stress, nutrient imbalances, poor sleep.
Speaker AIf someone's not sleeping well, I'm not giving them peptides until they're.
Speaker AUntil they've got their sleep on board, because it's so critical, just like you, Dana.
Speaker ABut basically, if you get your whole system healthier, you'll be producing more peptides.
Speaker AWith aging, production just falls off.
Speaker AAnd to some degree, if somebody is really struggling and can't right themselves on their own, with all of the lifestyle pieces all nicely in place, hormones optimized, we're gone, as metabolically healthy as we can, inflammation as low as we can, then I would suggest let's look at peptides.
Speaker AYeah, I think there's nuance there, but I do think that anybody over about 45 or 50, even 40, isn't going to have the levels that they were before of a lot of different peptides.
Speaker AAnd actually, when GLP1 came out, there was a woman, doctor, Tina Moore, she's a doctor out of California.
Speaker ABut she runs on this interesting theory that we actually have a GLP1 deficiency, many of us, and by adding it back, we're getting all of this rebalancing.
Speaker AAnd that deficiency can come from, like years of cyclical dieting.
Speaker AIt can come from stress, inflammation, disease, processes, undereating, over exercising, that kind of stuff.
Speaker AThose products only help a little tiny amount for many of us because we're maybe beyond an age or there's so much going on in the system to correct that sometimes jumping in with a peptide like GLP1 to replenish, restore can really help.
Speaker AThere is A doctor called Dr. Salas Whelan.
Speaker AShe's amazing, out of New York, she's actually from Mexico, and she studied obesity, GLP1s, and this stuff.
Speaker AAnd she's like, GLP1.
Speaker AGive people back this ability to sense fullness.
Speaker AMaybe they never had it to begin with.
Speaker ALike it runs in families.
Speaker AAnd these people are, they're eating a perfect diet, they're exercising, they're doing all the things and they still can't lose the weight.
Speaker AThere's something else going on and it's not inflammation, it's not a disease process.
Speaker ASometimes genetically people just don't have the nuts and bolts, you know.
Speaker ASo, yeah, there's that development too.
Speaker COkay.
Speaker CI have so many questions I can really relate to.
Speaker CI can really relate to what you're saying.
Speaker CFor me, it's not necessarily weight struggles.
Speaker CI know how to manipulate it when I really want to, but it's more just general kind of health issues, gut health and stuff like that, that just bother me.
Speaker CI'm just ultra sensitive, so I'm going to feel everything just 10 times more.
Speaker CAnd so I constantly have conversations with my functional medicine doctor where I'm like, doctor, I'm doing everything right.
Speaker BI'm doing this and I'm doing this and I'm doing that.
Speaker CAnd I'm waking up at 4:30 in the morning with cortisol out of the roof and I'm still dealing with stomach and all the things.
Speaker CAnd she's like, yeah, me too.
Speaker ASo I'm like, oh, okay.
Speaker CI go, my clients all feel amazing, by the way.
Speaker CShe's like, yeah, mine too.
Speaker CSo I don't know.
Speaker CBut my curiosity is about cortisol.
Speaker CIs there like a magical peptide that most of us need that can help reduce fucking cortisol?
Speaker CSay yes, please.
Speaker AOkay, the short answer is no, but like understanding why the cortisol is high could lead to a peptide that can help.
Speaker COh, interesting.
Speaker AYeah.
Speaker AIs it the gut?
Speaker AIs it an imbalanced immune system?
Speaker AIs it like chronic inflammation?
Speaker AIs it your hormones are out of balance and that's not really a peptide problem?
Speaker AYeah, I think that getting to the root cause and then figuring out a problem because there's not like cortisol is maybe a general bodily stress response that doesn't, isn't particularly linked to one thing only.
Speaker AIt's.
Speaker AThere could be all these inputs to that pathway.
Speaker AYou know what I'm saying?
Speaker COkay, so follow up question.
Speaker CIf someone comes up to you, pretend they're like me and they have a list of things and they're, they're all connected and yet somehow don't seem connected.
Speaker CThe spiel, what do you do then?
Speaker CWhat do you do in ter?
Speaker CDo you have a multi peptide vitamin thing that you can take daily?
Speaker CLike, how do you tackle many things because often people who do have autoimmune issues or just low immune will have numerous problems.
Speaker CRight.
Speaker CIt's not usually only I'm losing my hair or only I'm not sleeping well.
Speaker CIt's usually a bunched up shit.
Speaker ABunched up shit.
Speaker ATotally good question.
Speaker AI would always start with a full symptom assessment number one and two, a full blood work panel.
Speaker AIdeally that includes hormones, that includes blood, nutrient and mineral balance, includes morning cortisol, inflammation markers, blood immune markers.
Speaker ASo I would try and integrate both things because on either side you only get a partial picture.
Speaker ARight.
Speaker AIf I ask you about all your symptoms, lots of those symptoms will come from.
Speaker ACould come from many different places.
Speaker AAnd so by having a blood panel, then that can point us in the right direction and then we'll start.
Speaker AI would start coming with all of the lifestyle pieces first, because you can take all the peptides you want, but if your body isn't healthy enough to support using them, much like you can take hormone replacement therapy, you can take all you want, but if you're inflamed and stressed and not sleeping and all these things, like, they're not going to work very well for you.
Speaker AYes, we can, we can add some and see what happens.
Speaker ALike in the case of autoimmune is that cortisol is high because you're like massively inflamed and that's contributing to you not sleeping well.
Speaker AThat's a different story.
Speaker AAnd so then I might say, okay, lifestyle pieces look good, you're eating a good diet, you're hydrated, et cetera, you're moving your body regularly, you kept your stress low.
Speaker ALet's start you on a peptide and see what happens.
Speaker ACan we shift that immune balance?
Speaker ASo multifactorial, but starting with symptoms and labs and then seeing.
Speaker AI, yeah, I think peptides are in that case for someone with chronic issues.
Speaker ANot the first place I start.
Speaker AIf someone comes to me and they're an optimizer and they've got all the things done, dialed, then great.
Speaker AStart you on some peptides as appropriate.
Speaker AYeah.
Speaker BOkay, I'm going to get back to our listener question because she specifically asked us about regulation and sourcing of peptides.
Speaker BAnd I can see from one of your two blog posts that I could find on peptides that you also talk about sourcing and if so, can we shift into that and where do we get it, how do we start and what's most important to know when you're, when you're diving into this?
Speaker BBecause also it's how we're taking it.
Speaker BRight.
Speaker BCause it's with an injection most of the time.
Speaker BAnd that can also be a little freaky.
Speaker ATotally.
Speaker AI'll preface this by saying I don't have my finger on the pulse in Europe as much as I do on this side of the water in North America.
Speaker ABut I will say that the regulatory landscape has been a literal shit show.
Speaker ALike, it is just like shit flying back and forth.
Speaker ALike RFK Jr has just announced actually on a podcast that they're going to reassess and take peptides off the do not compound list very soon, which is very positive.
Speaker AHistorically, peptides are a gray area and they still are.
Speaker AAnd so you know that getting them is tricky.
Speaker ASo we have seen, because of the surge in popularity, lots of sketchy peptide companies popping up all over the Internet wanting to sell us cheap peptides.
Speaker AAnd yes, that is a disaster.
Speaker ANever buy from those companies, please.
Speaker ATypically, getting peptides is a little bit tricky because you need to work with often a functional medicine provider, ideally someone who has specialist training in peptides, because medical schools generally don't cover this topic.
Speaker AThat specialist training is in addition to.
Speaker AAnd then they would order peptides for you through a official compounding pharmacy.
Speaker AYou can't get these from big pharma yet because they're not.
Speaker AThey're, like I said, in this gray area, not approved.
Speaker AMost of them, Some of them are approved.
Speaker AActually.
Speaker AThymosin Alpha 1 has been approved and it is approved in Europe.
Speaker ASo you can get it through doctors there.
Speaker AI can't remember the name of it, but in general, for the average person, member of the public to get them, it's tricky and it costs a lot of money to do through a compounding facility.
Speaker AThere are a lot of clinics that I know functional medicine providers that have said, you know what, screw this.
Speaker ABecause of all of the regulatory theft and because the FDA made them illegal to compound, they have been going quietly.
Speaker AOther sources that would be considered gray market, but that have production facilities that are with an ISO certification number which guarantees a certain degree of purity, et cetera.
Speaker AI know a bunch of people, lots of people who are doing that and quietly getting peptides for patients that way, or they are actually getting them manufactured themselves and which is like something that they're really sticking their nook out to do because they know how powerful these things are.
Speaker ABut it's been really tricky for providers and I think that in parts of Europe it's easier because your peptides have been on the scene a lot longer.
Speaker AAs I mentioned, they were pioneered in Russia.
Speaker ATheir standard issue there basically like everybody takes peptide.
Speaker AFrom what I'm understanding, what I read online and what I hear from doctors in Europe and then in Eastern Europe too, they're much more popular and easy to get.
Speaker AI don't have specific sources over there per se that I could offer you and in confidence that they would be like legit.
Speaker ABut I know there's companies that are doing it well that are being used by functional medicine providers over there.
Speaker ASo that's a long winded answer to Tina's question to say it's freaking tough.
Speaker CSorry, sister.
Speaker ATough.
Speaker CYeah.
Speaker AThe landscape's changing, but yeah.
Speaker CAnd hopefully it will change more soon.
Speaker CBut what peptides would one start with if they do find the right source and hopefully are working with the right person?
Speaker CBut what if they just want to start and experiment and they have enough money for it?
Speaker CWhat should they start with?
Speaker CGive us three, because I feel like at least two we've already heard about.
Speaker AYeah, okay.
Speaker AThis is not medical advice.
Speaker CI know.
Speaker ADisclaimer that I will give you the top, top ones that people like myself that I use and in the longevity space are most popular with the sort of biggest bang for your buck, as it were.
Speaker ABPC157 is one of those because it has such wide ranging positive effects.
Speaker AIt's a tissue healer, it's anti inflammatory, it helps with brain function.
Speaker AIt's.
Speaker AIt helps also with immune balance.
Speaker ALike it incredible.
Speaker AYou'll read a lot about that one online.
Speaker AGHK or GHK Copper.
Speaker AThat is the actual sequence of the amino acids.
Speaker AIt's really tiny.
Speaker AIt is all about connective tissue.
Speaker ASo the beauty industry loves it.
Speaker ASkin, hair, nails, all that stuff.
Speaker AYou'll see it advertised in facial creams and all sorts of products.
Speaker ANow it's also available injectable and orally, I should say some are available orally.
Speaker ABPC157 and GHK copper, GHK Cu.
Speaker AI'm actually taking oral form of both of those right now myself noticing I always notice so much.
Speaker ASo good.
Speaker AI get so good on these things.
Speaker ABuild muscle faster, recover faster, that kind of stuff.
Speaker AMy skin looks better.
Speaker AThese things help organ function.
Speaker AGHK also affects, let's say the youthfulness of cells.
Speaker ASo it affects the expression of thousands of genes in your body, which is really cool.
Speaker AOther popular ones for let's say if you're looking to build muscle, sleep better, maybe shed some fat, just feel more energized, bounce.
Speaker AHave a little bit better hormone bounce.
Speaker AThere's a combination.
Speaker AThere's these growth Hormone secretagogues or growth hormones, secreting hormones and they act on the growth hormone pathway.
Speaker ASo those are called like Epamorelin, CJC 1295, Tessamorelin.
Speaker AThere's a whole cluster of them and they all impact growth hormone function, but different from how a bodybuilder would take growth hormone, which is like a disaster.
Speaker AThis is actually a much safer and more physiological way to stimulate growth hormone release in a pulsatile way in your body, which is how your body likes growth hormone.
Speaker AIt's not like giving a massive dose of growth hormone in cell.
Speaker AWhat these things do is they stimulate the receptor or hormone release so that it's more physiological.
Speaker AAnd that like growth hormone is so wide reaching.
Speaker AIt's one of the things that drops off over time with age.
Speaker AAnd so that's why I mentioned like a lot of people will feel improved sleep, better energy, better hormone balance.
Speaker AThey'll see improved libido, sometimes muscle gain, collar bones, a little fat loss, that kind of stuff.
Speaker AGrowth pathways.
Speaker AAwesome.
Speaker AThere's a few others.
Speaker AThat's a few.
Speaker AThere's a bunch more that I would use like in my practice, but those are times I would cycle on and off.
Speaker AAnd then the last one is epitalon, which is a pineal gland peptide.
Speaker AAnd it can help to regulate like leap and helps with longevity overall according to the Russian studies, which are actually quite amazing.
Speaker ASo it's one of the few that they were seeing, is actually able to lengthen lifespan by between anywhere between two and 10 years when given to older people, which is pretty cool.
Speaker ALike they did some experiments in people over 60 years old and over these long duration studies and found lifespan extension.
Speaker ASo it, and it's acting not just on melatonin signaling and everything, but downstream of that.
Speaker ABut it acts at like the level of the DNA to change epigenetics around aging, which is really interesting.
Speaker AThat one has.
Speaker AYeah, that one is less proven out in like other data sources, less studied but like fascinating.
Speaker BSo Mary, when we talked to you, feels like eons ago you were building some program and you were talking about supporting women in their 40s and beyond.
Speaker BAnd we know that you have a program and you're helping people with this and I know from your blog post, and again we're going to link all this material because in your blog post you link other people's materials and I think that's a really good way for people to read on their own, do some of your own research.
Speaker BBut at least you have some starting place and you have this program called better beyond 40.
Speaker BAnd you talk about how now with these changes in regulations, you're really excited about using peptides in your program.
Speaker BAnd we've talked a little bit about like, where do people start?
Speaker BSo maybe now we're marrying these things together.
Speaker BSo how do you approach this in your program with the people that you help?
Speaker AYes, absolutely.
Speaker AI recently just decided because of the changing landscape and peptides coming back into the light with this recent shift in the FDA status that it legitimizes, then more, it's a little bit safer for me to go ahead and be like, okay, this stuff is really good and feel really supported by that because it is such a gray area.
Speaker ASo I decided to fold peptides into my work with women, perimenopause and menopause women.
Speaker ASo women in their late 30s through early 60s.
Speaker AAnd in my program, I it's a 12 week program, can be done anywhere in the world.
Speaker AAnd the whole idea is optimizing hormonal and metabolic balance so people can repeat their symptoms, whatever they're struggling with.
Speaker AIt all looks different for everyone and they can lose weight permanently.
Speaker AAll of the conventional stuff that we go through is unsupported by conventional medicine.
Speaker AAnd so I bring in a lot of lifestyle natural based support and that's always my angle.
Speaker AAnd we look to address the underlying imbalances and inflammation pop up in the body as our hormones, our hormonal landscape changes with time.
Speaker ASo that means metabolic health, the gut, the liver, the thyroid, all of the organ system, the adrenals, the high cortisol, that's a thing, the immune imbalance.
Speaker ASo what I'll do is I'll start with all of the lifestyle medicine pieces.
Speaker AOften I will introduce the idea of hormone replacement.
Speaker ADone well.
Speaker AThat's a nuanced conversation and most of it is not done well.
Speaker AAnd then I'm going to bring in the peptides to support once we have those foundation pieces in place.
Speaker AAnd there's definitely a few for the midlife woman that become really relevant when we can't resolve certain struggles or there has been like a lifelong issue with, with obesity or with autoimmunity or allergies like we talked about before, or pain or inability to exercise because of an injury.
Speaker AStill, you can bring in peptides to finally resolve those issues.
Speaker ASo I'm pretty excited about it.
Speaker AIt's not the first place we start, but it gets folded into the mix if and as appropriate.
Speaker BYeah.
Speaker BVery cool.
Speaker CVery.
Speaker CYou're awesome.
Speaker CYou're awesome.
Speaker CAnd you really, I mean, you managed to beautifully build this program.
Speaker CWhere you're beautifully unfolding things and tackling things from all directions, which I love.
Speaker CI think that's so important because people expect just this or just that.
Speaker CAnd it's just a beautiful kind of building blocks method of let's worry about the basics first and then let's move on to the next step and then let's move on to the peptides because you need to optimize a few things beforehand.
Speaker CSo, Gina, I hope this answers your frickin question.
Speaker CAnd if not, leave us another voice message and let us know what we should ask Mary next because this is definitely not the last time we will be interviewing you, Mary.
Speaker CYou're one of our best and most popular guests.
Speaker CSo we're super happy.
Speaker AYeah.
Speaker AThanks, Pete.
Speaker AAppreciate that.
Speaker AThanks friends for listening.
Speaker AI love this.
Speaker BAnd we do need to plug your podcast because you just started a podcast called the better Beyond 44 by Dr. Mary Pines.
Speaker BSo I'm sure you can find that that's on your website, which actually I'm telling people now.
Speaker BI think if you listen to a podcast, you should probably go to the website first because there's usually a lot more information there along with blog posts and other stuff.
Speaker BBut of course you can find it on all the podcast platforms.
Speaker BAnd you just had Donna on and.
Speaker AIt was an awesome conversation.
Speaker BAnd Donna told me, she told me the other day, she's like, by the way, I was on Mary's podcast, we need to cross reference this.
Speaker BAnd I'm like, on.
Speaker COn our website.
Speaker BI was like, okay.
Speaker BAnd then I like put that away and totally forgot about it.
Speaker BAnd then when today, when I went on to open up all your articles, I'm like, let's go see her recent post.
Speaker BAnd I'm like, is cheating on me with another podcast?
Speaker BBut it sounds, Yeah, I had to.
Speaker AShare, I had to share her journey and her wisdom with all the ladies in my program and with the world.
Speaker AYeah.
Speaker ASuch a wild, amazing ride and such a wise woman.
Speaker CYeah.
Speaker BDonna's pain gets a lot of listeners on our channel.
Speaker CPeople love hearing me in pain.
Speaker AOh, you're so positive about the way you speak to the pain and undoing the pain.
Speaker AAnd that's something everybody needs to hear.
Speaker AI had someone in my program reach out to say, oh my God, that was.
Speaker AThat is totally me.
Speaker AAnd I really needed to hear that.
Speaker ASo thank you.
Speaker AYeah.
Speaker AYeah.
Speaker AIt was elated.
Speaker AYeah.
Speaker BWell, thank you so much.
Speaker AThank you.
Speaker BThank you for hosting me.
Speaker AYeah.
Speaker BAnd again, we will have you back because for sure we will have more questions in the future.
Speaker AAll the best.
Speaker BAll the best.
Speaker BThanks for being here.
Speaker AThank you.
Speaker AThanks for the work you're both doing.
Speaker AIt's so important getting this out to the world.
Speaker AI'm so honored to be on the show, and I look forward to.
Speaker BYeah.
Speaker AConnecting again.
Speaker AWrite us more letters, everybody.
Speaker CYes, please.
Speaker AMore questions.
Speaker ACool.
Speaker AThanks, guys.
Speaker ABye.











